Bursaspor 0 United 3
United took the three points on offer in the Ataturk Stadium with a fine second half performance.
Sir Alex, having left several players at home suffering from a virus, chose to play five in midfield with Berbatov as the lone striker.
Our man-of-the-moment, Javier Hernadez, dropped to the bench with Obertan making his second start of the season.
With Rio Ferdinand left behind to protect his back, Chris Smalling was given the centre back berth alongside Nemanja Vidic.
United - Van der Sar, Evra, Smalling, Vidic, Rafael, Nani, Carrick, Scholes, Fletcher, Berbatov, Obertan
Subs - Kuszczak, Brown, O`Shea, Park, Hernandez, Bebe
The game got off to a cagey start but United carved out a half chance when Berbatov met an Evra cross but couldn`t get enough power behind the headed effort to test Ivankov in the Bursaspor goal.
In a half of few chances United lost Nani to what appeared to be a groin injury with Park coming on to replace him.
As a pretty uneventful half drew to a close, United thought they had scored when Scholes netted, unfortunately the referee had noticed a deliberate handball as Scholes brought the ball under control.
Not an impressive forty-five minutes from United but Bursaspor were not much beter.
Half Time - Bursapor 0 United 0
Any thoughts that the second half would be as dull as the first half were blown away when Darren Fletcher put United ahead with three minutes of the half gone.
The goal came after Carrick had delivered an exquisite ball that found Fletcher in space and a touch later he`d rifled in his second goal of the competition.
Bursaspor 0 United 1 (Fletcher 48 mins)
Sir Alex replaced Fletcher with Bebe as United appeared in little danger of conceding an equaliser. As the half progressed United doubled their lead courtesy of Gabriel Obertan. The Frenchman cut inside Tandogan to fire into the net.
Bursaspor 0 United 2 (Obertan 73 mins)
A minute later the lead was 3-0 when Bebe scored four minutes later to put the game to bed.
Bursaspor 0 United 3 (Bebe 77 mins)
Qualification almost guaranteed but there will, no doubt, be harder games ahead as the boss hunts down that third Champions League trophy he desires.