Fergie on Rio & Neville (AUDIO)
And so the sixth meeting inside a year between the two sides comes to a head at Old Trafford. Man United take on Roma a week after Cristiano Ronaldo's header and Wayne Rooney's tap in meant in all likelihood, United will progress.
Sir Alex Ferguson has suffered some headaches though since that win in the Italian capital. He lost Nemnja Vidic firstly, before Rio Ferdinand hobbled out of the draw with Middlesbrough leaving a defensive crisis at Old Trafford - the duo's roles have been integral to the Champions and current league leader's season.
However, there's good news from Fergie as Ferdinand's injury is not as bad as first feared and hea may even feature against Roma whilst club captain Gary Neville, who hasn't appeared since March 2007 through injury, may make his first appearance after returning from an injury nightmare.
The winners take on either Schalke or Barcelona in the Semi-Final stage.
Press Conference Length: 2 Min 30 Sec
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